Effectiveness of Anidulafungin in Eradicating Candida Species in Invasive Candidiasis

Anidulafungin versus fluconazole for invasive candidiasis.

BACKGROUND Anidulafungin, a new echinocandin, has potent activity against candida species. We compared anidulafungin with fluconazole in a randomized, double-blind, noninferiority trial of treatment for invasive candidiasis. METHODS Adults with invasive candidiasis were randomly assigned to receive either intravenous anidulafungin or intravenous fluconazole. All patients could receive oral fl...

Cost-effectiveness analysis of anidulafungin versus fluconazole for the treatment of invasive candidiasis.

BACKGROUND Anidulafungin was found to be non-inferior to and possibly more efficacious than fluconazole for treatment of invasive candidiasis (IC) in a major randomized clinical trial (RCT). There are no data comparing the cost-effectiveness between azoles and echinocandins in treating IC. This economic analysis investigated the cost-effectiveness of anidulafungin compared with fluconazole for ...

Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis

BACKGROUND Candidaemia and other forms of invasive candidiasis (C/IC) in the intensive care unit are challenging conditions that are associated with high rates of mortality. New guidelines from the European Society for Clinical Microbiology and Infectious Diseases strongly recommend echinocandins for the first-line treatment of C/IC. Here, a cost-effectiveness model was developed from the Unite...

Anidulafungin was noninferior to fluconazole for invasive candidiasis.

M e t h o d s Design: Randomized, controlled, noninferiority trial. Allocation: {Concealed}†.* Blinding: Blinded.* Setting: 47 institutions in 6 countries in Europe and North America. Follow-up period: 6 weeks after completion of therapy. Patients: 261 patients ≥ 16 years of age who had candidemia (≥ 1 positive blood culture) or other forms of invasive candidiasis (a positive culture obtained f...

Safety and Efficacy of Anidulafungin in the Treatment of Invasive Candidiasis in Children